Adenosine exerts a negative inotropic effect in guinea pig atrial myocytes primarily by shortening action potential duration via activation of the inwardly rectifying K+ current, rather than by directly decreasing L-type Ca2+ current.
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APD shortening mediates adenosine negative inotropy in guinea pig atria; leaves open translation to human electrophysiology or therapy.
Wang et al. (1994) studied this question.
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