Cholesteryl ester synthesis by the microsomal fraction from rat hepatoma cells was stimulated by preincubation of the microsomal fraction with lipoproteins obtained from hyperlipemic rabbit sera. Lipoproteins from normolipemic sera had no stimulatory effect. Growth of cells in hyperlipemic rabbit sera also increased microsomal cholesteryl ester synthesis. Increased cholesteryl ester synthesis is accompanied by an increased microsomal-free cholesterol content.
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Rothblat et al. (1977) studied this question.