New highly practical methods are presented for aerobic oxidation of secondary alcohols with a nitroxyl radical in combination with HNO 3, NaNO 2, or both as cocatalysts. Diverse nitroxyls are compared, including several novel bicyclic derivatives. Catalyst systems with the readily available nitroxyls, 9-azabicyclo[3.3.1]nonane- N -oxyl (ABNO) and 9-azabicyclo[3.3.1]nonan-3-one- N -oxyl (keto-ABNO), are optimized in acetic acid or acetonitrile as the solvent. The reactions are compatible with substrates bearing diverse functional groups and proceed efficiently under mild conditions at ambient pressure and temperature.
No takes yet. Share an insight, caveat, or question.
Lauber et al. (2013) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: