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May extend NEP/RAAS insights in cardiorenal models; hypothesis-generating and should not yet change practice.
Cardiorenal Research Laboratory, Department of Medicine, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA Correspondence to John C. Burnett, Jr, MD, Cardiorenal Research Laboratory, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA Abbreviations ACE: angiotensin-converting enzyme ANP: atrial natriuretic peptide cGMP: cyclic guanosine 5-monophosphate NEP: neutral endopeptidase 24-11 RAAS: renin-angiotensin-aldosterone system VPI: vasopeptidase inhibitors
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John C. Burnett (2000) studied this question.
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