Why the study?
Does candoxatril lower blood pressure and alter humoral systems in patients with essential hypertension?
Does candoxatril lower blood pressure and alter humoral systems in patients with essential hypertension?
The blood pressure lowering effect of candoxatril in hypertension is counterbalanced by the activation of vasoconstrictor systems.
Suggests limited utility of candoxatril monotherapy in hypertension; extends understanding of neurohormonal counter-regulation with NEP inhibition.
Candoxatril augments the effects of ANF and lowers blood pressure in patients with hypertension. However, the antihypertensive effects may be offset by increased angiotensin-aldosterone and sympathetic nervous system activity. The blood pressure response to endopeptidase inhibition in hypertensive patients may depend on the relative effects on humoral vasodilator (including ANF) and vasoconstrictor (including the angiotensin-aldosterone and sympathetic) systems.
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Richards et al. (1993) studied this question.
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