April 1, 1993
View Full PaperChronic inhibition of endopeptidase 24.11 in essential hypertension: evidence for enhanced atrial natriuretic peptide and angiotensin II
Structured PICO
Does candoxatril lower blood pressure and alter humoral systems in patients with essential hypertension?
P
Population
Patients with essential hypertension
I
Intervention
Candoxatril (endopeptidase 24.11 inhibitor)
O
Outcome
Blood pressure and humoral system activity (ANF, angiotensin-aldosterone, sympathetic nervous system)surrogate
The blood pressure lowering effect of candoxatril in hypertension is counterbalanced by the activation of vasoconstrictor systems.
Abstract
Candoxatril augments the effects of ANF and lowers blood pressure in patients with hypertension. However, the antihypertensive effects may be offset by increased angiotensin-aldosterone and sympathetic nervous system activity. The blood pressure response to endopeptidase inhibition in hypertensive patients may depend on the relative effects on humoral vasodilator (including ANF) and vasoconstrictor (including the angiotensin-aldosterone and sympathetic) systems.