Effect of inhibition of endopeptidase 24.11 on responses to angiotensin II in human volunteers.
Why the study?
Does candoxatril alter angiotensin-induced changes in plasma angiotensin II, aldosterone, atrial natriuretic factor, and blood pressure in normal volunteers?
Population
16 normal human volunteers (two groups of 8)
Comparison
Candoxatril 25 mg every 12 hours or 100 mg every… vs Matching placebo for 5 days, with stepwise…
Design
RCT, Balanced randomized crossover, Double-blind, placebo-controlled
Follow-up
5 days
Authors
Discussion
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Implication
Candoxatril may potentiate angiotensin II effects; extends understanding of neutral endopeptidase 24.11 inhibition on the renin-angiotensin axis.
Structured PICO
Does candoxatril alter angiotensin-induced changes in plasma angiotensin II, aldosterone, atrial natriuretic factor, and blood pressure in normal volunteers?
P
Population
16 normal human volunteers (two groups of 8)
I
Intervention
Candoxatril (oral inhibitor of endopeptidase 24.11) 25 mg every 12 hours (group 1) or 100 mg every 12 hours (group 2) for 5 days, with stepwise infusions of angiotensin II (2, 4, and 8 ng/kg per minute) on day 5
C
Comparator
Matching placebo for 5 days, with stepwise infusions of angiotensin II on day 5
O
Outcome
Angiotensin-induced changes in plasma angiotensin II, aldosterone, and atrial natriuretic factor concentrations and blood pressuresurrogate
Inhibition of endopeptidase 24.11 with candoxatril enhances plasma angiotensin II concentrations and pressor responses during angiotensin II infusion in normal volunteers.
Cite This Study
Richards et al. (1992) studied this question.