Key result
A history of cancer was associated with an increased risk of comorbid cardiovascular disease compared to non-cancer subjects (OR 1.52; 95% CI 1.34-1.72).
Why the study?
CVD is a common cause of death in cancer survivors, but the risk of comorbid CVD according to specific cancer site required evaluation.
Does being a long-term cancer survivor increase the risk of comorbid cardiovascular disease in Korean adults over 40?
Cross-Sectional (n=47,171)
No
Does being a long-term cancer survivor increase the risk of comorbid cardiovascular disease in Korean adults over 40?
Odds Ratio: 1.52 (95% CI 1.34–1.72)
Long-term cancer survivors, particularly those with a history of lung cancer, have a significantly increased risk of comorbid cardiovascular disease.
May warrant closer CVD risk assessment in cancer survivors; leaves open causality and confounding.
BACKGROUND: Cardiovascular disease (CVD) is a common cause of death in cancer survivors. We evaluated the risk of comorbid CVD in long-term cancer survivors according to specific cancer site. METHODS: Study subjects included 47,171 Koreans aged over 40 years who visited a health promotion centre between 2010 and 2012. Information on CVD and cancer was obtained from self-report. Comorbid CVD was defined as stroke, myocardial infarction or angina pectoris. The risk of comorbid CVD in survivors was compared with that in non-cancer subjects using multiple logistic regression analysis. RESULTS: Among cancer survivors (n = 3,753), 330 events of CVD were reported. Age- and sex-adjusted analysis showed that odds ratio (OR) for comorbid CVD in survivors was 1.52 (95% confidence interval: 1.34-1.72) compared to non-cancer subjects (n = 43,418). After adjusting for health-related behaviour and medical history, only lung cancer survivors had 2.44 (1.01-5.89)-fold higher OR for CVD. In stratified analysis, significantly higher OR for CVD was evident in lung cancer survivors with hypertension who did not perform regular physical exercise. CONCLUSIONS: Adult cancer survivors may have an increased risk of comorbid CVD that might be mediated in part by known cardiovascular risk factors depending on the specific cancer site.
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Shin et al. (2019) conducted a cross-sectional in Cardiovascular disease in cancer survivors (n=47,171). History of cancer vs. Non-cancer subjects was evaluated on Comorbid CVD (stroke, myocardial infarction or angina pectoris) (OR 1.52, 95% CI 1.34-1.72). A history of cancer was associated with an increased risk of comorbid cardiovascular disease compared to non-cancer subjects (OR 1.52; 95% CI 1.34-1.72).
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