Key result
Women with type 1 diabetes had a substantially higher standardized mortality ratio for ischemic heart disease than men (21.6 vs 5.8), with the greatest risk observed in the early-onset cohort.
Why the study?
Does ischemic heart disease mortality among patients with type 1 diabetes depend on the age at onset of diabetes and sex?
Population
17,306 patients with type 1 diabetes in a Finnish population-based cohort, categorized into early-onset and…
Design
Cohort
Follow-up
433,782 person-years
Authors
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Signals markedly elevated IHD mortality in women with early-onset T1D; extends sex-disparity data but leaves optimal interventions open.
Cohort (n=17,306)
Does ischemic heart disease mortality among patients with type 1 diabetes depend on the age at onset of diabetes and sex?
Effect estimate: SMR 21.6 (95% CI 17.2-27.0)
Women with early-onset type 1 diabetes have an exceptionally high relative risk of ischemic heart disease mortality compared to the background population, emphasizing the need for early and aggressive risk factor management.
Harjutsalo et al. (2013) conducted a cohort in Type 1 diabetes (n=17,306). Female sex and early age at onset of diabetes vs. Male sex and late age at onset was evaluated on Long-term ischemic heart disease (IHD) mortality (SMR 21.6, 95% CI 17.2-27.0). Women with type 1 diabetes had a substantially higher standardized mortality ratio for ischemic heart disease than men (21.6 vs 5.8), with the greatest risk observed in the early-onset cohort.
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