Key result
GABA A receptor activation via oral diazepam blunted the reduction in muscle sympathetic nerve activity at the onset of static handgrip exercise in young, healthy individuals.
Why the study?
Does oral administration of diazepam modulate muscle sympathetic nerve activity at the onset of static handgrip exercise in young, healthy individuals?
Does oral administration of diazepam modulate muscle sympathetic nerve activity at the onset of static handgrip exercise in young, healthy individuals?
GABA A receptor activation with diazepam blunts the reduction in muscle sympathetic nerve activity at the onset of static exercise, providing insight into neural circuitry controlling sympathetic outflow.
Answers are grounded in this paper and cite their sources.
May modulate sympathetic responses during exercise; leaves open relevance to patients with cardiovascular disease.
In this study, we found that the reduction in muscle sympathetic nerve activity at the onset of static handgrip exercise was blunted following GABA A receptor activation with oral administration of diazepam in young, healthy individuals. The present findings provide novel insight into neural circuitry mechanisms controlling muscle sympathetic outflow during exercise in humans.
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Teixeira et al. (2021) studied this question. GABA A receptor activation via oral diazepam blunted the reduction in muscle sympathetic nerve activity at the onset of static handgrip exercise in young, healthy individuals.
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