Key result
Attempted handgrip during partial neuromuscular blockade caused significantly smaller increases in muscle sympathetic nerve activity (+56% vs +217%) and mean arterial pressure than actual handgrip.
Why the study?
Does central command (intent to exercise) increase sympathetic discharge to resting skeletal muscle during static exercise in humans?
Population
20 healthy subjects (9 in the main experiment, 11 in an additional experiment)
Comparison
Attempted handgrip during partial neuromuscular… vs Actual static handgrip at 15% and 30% maximal…
Design
Other
Authors
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Central command modestly augments MSNA and pressure without contraction; leaves open its dominance over peripheral feedback in exercise sympathoexcitation.
Does central command (intent to exercise) increase sympathetic discharge to resting skeletal muscle during static exercise in humans?
Absolute Event Rate: 56% vs 217%
p-value: p=<0.05
Central command (the intent to exercise) alone can significantly increase muscle sympathetic nerve activity, arterial pressure, and heart rate, even without actual muscle contraction.
Victor et al. (1989) studied Healthy subjects (n=20). Attempted handgrip during partial neuromuscular blockade (tubocurarine chloride) vs. Actual static handgrip at 30% maximal voluntary contraction was evaluated on Muscle sympathetic nerve activity (p=<0.05). Attempted handgrip during partial neuromuscular blockade caused significantly smaller increases in muscle sympathetic nerve activity (+56% vs +217%) and mean arterial pressure than actual handgrip.
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