Overexpression of KLF2 alleviated tight junction protein degradation and blood-spinal cord barrier damage by tuning autophagy-lysosomal pathway dysfunction, improving motor function recovery in SCI mice.
Does KLF2 overexpression improve blood-spinal cord barrier integrity and functional recovery in a mouse model of spinal cord injury?
KLF2 overexpression protects blood-spinal cord barrier integrity and promotes functional recovery after spinal cord injury by restoring endothelial autophagic flux.
Endothelial KLF2 as one of the key contributors to SCI-mediated ALP dysfunction and BSCB disruption. KLF2 could be a promising pharmacological target for the management and treatment of SCI.
He et al. (Sun,) conducted a other in Spinal cord injury. KLF2 overexpression vs. Control lentivirus (LV-Con) or shRNA was evaluated on Blood-spinal cord barrier integrity and motor function recovery. Overexpression of KLF2 alleviated tight junction protein degradation and blood-spinal cord barrier damage by tuning autophagy-lysosomal pathway dysfunction, improving motor function recovery in SCI mice.