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Marine-derived compounds show promise as novel renewable sources for antithrombotic therapy.
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Marine organisms exhibit some advantages as a renewable source of potential drugs, far beyond chemotherapics. Particularly, the number of marine natural products with antithrombotic activity has increased in the last few years, and reports show a wide diversity in scaffolds, beyond the polysaccharide framework. While there are several reviews highlighting the anticoagulant and antithrombotic activities of marine-derived sulfated polysaccharides, reports including other molecules are sparse. Therefore, the present paper provides an update of the recent progress in marine-derived sulfated polysaccharides and quotes other scaffolds that are being considered for investigation due to their antithrombotic effect.
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Carvalhal et al. (2019) conducted a review in Thrombosis. Marine-derived sulfated polysaccharides and other marine natural products was evaluated on Antithrombotic and anticoagulant activity. Marine-derived sulfated polysaccharides and diverse non-polysaccharide scaffolds are being investigated as renewable sources of potential antithrombotic agents.
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