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In a canine model, experimentally induced atherosclerosis impairs coronary vasomotor reactivity in proportion to disease severity.
The atherogenic regimen imposed upon the animals studied here resulted in several distinct abnormalities of the coronary circulation. The structure of the coronary arteries was modified by extensive atheromatous deposits. During control states before the administration of vasoactive drugs, coronary flow per unit of net propulsive force and heart weight was unvaried or increased. The ability of the atheromatous coronary tree to increase or decrease its vasomotor tonus was markedly curtailed. The abnormalities mentioned here were proportional with the severity of the atherogenic regimen.
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Cross et al. (1962) studied this question.
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