Key result
Coronary vasodilators increased coronary blood flow and decreased vascular resistance in both normal and sclerotic dogs, though the amplitude of response was significantly less in dogs with coronary sclerosis.
Why the study?
Do coronary vasodilators improve coronary blood flow and vascular resistance in dogs with experimental coronary sclerosis compared to normal dogs?
Do coronary vasodilators improve coronary blood flow and vascular resistance in dogs with experimental coronary sclerosis compared to normal dogs?
Coronary vasodilators improve coronary hemodynamics in experimental coronary sclerosis, though the response is blunted compared to healthy controls.
Effects in canine sclerosis are hypothesis-generating; leaves open translation to human coronary disease.
Observations are presented about the effects of four kinds of coronary vasodilators (dipyridamole, oxyfedrine, prenylamine and trimetazidine) on coronary circulation in the heart with coronary sclerosis which has been induced by intravenous injection of allylamine in the dog. Following results are obtained: 1) All of the drugs examined increase coronary blood flow and decrease coronary vascular resistance in the dogs with coronary sclerosis as well as in normal dogs. 2) An amplitude of response of coronary circulation to the coronary vasodilators is significantly less in the dogs with coronary sclerosis than in the normal dogs. 3) The clinical value of coronary vasodilator has been discussed.
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Daiji Saito (1976) studied Experimental coronary sclerosis. Coronary vasodilators (dipyridamole, oxyfedrine, prenylamine, trimetazidine) vs. Normal dogs was evaluated on Coronary blood flow and coronary vascular resistance. Coronary vasodilators increased coronary blood flow and decreased vascular resistance in both normal and sclerotic dogs, though the amplitude of response was significantly less in dogs with coronary sclerosis.
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