Why the study?
Does diazoxide administration reduce VLDL production and serum triglyceride concentration in a patient with partial lipodystrophy and hyperinsulinaemia?
Does diazoxide administration reduce VLDL production and serum triglyceride concentration in a patient with partial lipodystrophy and hyperinsulinaemia?
In a patient with partial lipodystrophy, reducing insulin levels with diazoxide decreased VLDL production and serum triglycerides, suggesting insulin's role in VLDL over-synthesis.
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Supports insulin's role in VLDL overproduction in partial lipodystrophy; hypothesis-generating and should not change practice.
A patient with partial lipodystrophy is described in whom hypertriglyceridaemia was accompanied by marked hyperinsulinaemia. The hyperlipidaemia was due to increased plasma levels of very low density lipoprotein (VLDL). Kinetic studies, performed after injection of autologous radioiodinated VLDL, indicated that the raised VLDL levels were associated with over-production of this lipoprotein. Administration of diazoxide led to a substantial fall in serum insulin levels, accompanied by reduction in VLDL production and in serum triglyceride concentration. The possible role of insulin in inducing hyperlipidaemia by causing over-production of VLDL is discussed.
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Chait et al. (1979) studied this question.
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