Key result
Among pediatric myocarditis patients without pre-ECMO cardiac arrest, longer intubation-to-cannulation time (≥18 hours) was associated with significantly lower odds of survival to hospital discharge (OR 0.09).
Why the study?
Children with acute myocarditis may rapidly deteriorate requiring ECMO, but understanding of best practices and the timing of ECMO initiation is lacking.
Does early ECMO cannulation after intubation improve survival to hospital discharge in pediatric patients with myocarditis?
Cohort (n=506)
Yes
Does early ECMO cannulation after intubation improve survival to hospital discharge in pediatric patients with myocarditis?
Odds Ratio: 0.09 (95% CI 0.02–0.4)
p-value: p=0.002
In pediatric patients with myocarditis requiring ECMO who have not experienced prior cardiac arrest, earlier cannulation after intubation is associated with significantly improved survival to hospital discharge.
Pre-cannulation factors may inform ECMO timing in pediatric myocarditis; leaves open optimal strategies pending prospective validation.
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Gutierrez et al. (2022) conducted a cohort in Pediatric myocarditis (n=506). Longer intubation-to-cannulation time (≥18 hours) vs. Shorter intubation-to-cannulation time (≤1 hour) was evaluated on Survival to hospital discharge (OR 0.09, 95% CI 0.02-0.40, p=0.002). Among pediatric myocarditis patients without pre-ECMO cardiac arrest, longer intubation-to-cannulation time (≥18 hours) was associated with significantly lower odds of survival to hospital discharge (OR 0.09).
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