A challenging undertaking: Stem cell transplantation for immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) syndrome

This is the authors' abstract. We don't add key points for this paper.

Immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) syndrome is a rare, life-threatening systemic autoimmune disorder caused by mutations in the forkhead box P3 (FOXP3) gene, which is required for the development and function of regulatory T cells and prevention of autoimmunity.1 Although most patients present in infancy with a clinical triad of intractable diarrhea, insulin-dependent diabetes, and eczematous dermatitis, some patients present with severe food allergies, other autoimmune manifestations, or both.