Expanding the Functional Group Compatibility of Small‐Molecule Microarrays: Discovery of Novel Calmodulin Ligands

This is the authors' abstract. We don't add key points for this paper.

The importance of the pKa value: Phenols, carboxylic acids, and compounds containing comparably acidic functional groups are covalently captured on a diazobenzylidene-functionalized glass surface. This new covalent slide-capture method has been used to print 6336 diversity-oriented synthesis-derived phenol-containing fused bicycles and tetracycles, from which new calmodulin ligands were identified (see schematic representation).