Key result
Intensified risk factor management in patients with Type 2 diabetes significantly improved the global arginine bioavailability ratio from 0.33 at baseline to 0.38 at 3 months (P=0.018).
Why the study?
Does intensified multifactorial risk factor intervention improve arginine bioavailability ratios in patients with Type 2 diabetes?
Population
41 patients with Type 2 diabetes not reaching treatment targets according to current local diabetes…
Comparison
Intensified multifactorial risk factor therapy… vs Baseline (pre-intervention values)
Design
Cohort
Follow-up
3 months
Authors
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Intensified risk factor management was associated with improved arginine bioavailability in T2D; hypothesis-generating for endothelial benefits and requires RCT confirmation.
Observational (n=41)
No
Does intensified multifactorial risk factor intervention improve arginine bioavailability ratios in patients with Type 2 diabetes?
Absolute Event Rate: 0.38% vs 0.33%
p-value: p=0.018
Intensified multifactorial risk factor management in Type 2 diabetes improves arginine bioavailability ratios, a surrogate marker for endothelial function, particularly in patients with shorter disease duration.
Tripolt et al. (2012) conducted an observational in Type 2 diabetes (n=41). Intensified risk factor management vs. Baseline was evaluated on Global arginine bioavailability ratio (p=0.018). Intensified risk factor management in patients with Type 2 diabetes significantly improved the global arginine bioavailability ratio from 0.33 at baseline to 0.38 at 3 months (P=0.018).
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