Key result
Acute exposure to 15% O2 significantly increased transfer function coherence (0.64 vs 0.46; P=0.028) and gain (0.86 vs 0.61; P=0.035) in the very-low-frequency range compared to normoxia.
Why the study?
Does acute exposure to normobaric mild hypoxia alter dynamic cerebral autoregulation in healthy men?
Population
15 healthy men
Comparison
Acute exposure to normobaric mild hypoxia vs Normoxic conditions (21% oxygen)
Follow-up
10 mins at each oxygen level
Authors
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May indicate impaired dynamic cerebral autoregulation during mild hypoxia in healthy men; leaves open clinical relevance and need for prospective studies.
Does acute exposure to normobaric mild hypoxia alter dynamic cerebral autoregulation in healthy men?
Absolute Event Rate: 0.64% vs 0.46%
p-value: p=0.028
Acute exposure to 15% oxygen increases arterial pressure oscillations and the dependence of cerebral blood flow fluctuations on blood pressure, suggesting impaired dynamic cerebral autoregulation in the very-low-frequency range.
Iwasaki et al. (2006) studied Healthy (n=15). Acute exposure to normobaric mild hypoxia vs. Normoxic conditions (21% O2) was evaluated on Transfer function coherence in the very-low-frequency range (p=0.028). Acute exposure to 15% O2 significantly increased transfer function coherence (0.64 vs 0.46; P=0.028) and gain (0.86 vs 0.61; P=0.035) in the very-low-frequency range compared to normoxia.
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