Key result
Physical activity was directly and significantly associated with increased PI3K mRNA expression in the visceral adipose tissue of obese adults.
Why the study?
The PI3K/Akt signaling pathway regulates glucose and lipid metabolism, prompting investigation into the association of PI3K and Akt expression in visceral and subcutaneous adipose tissue with daily physical activity in non-diabetic obese and non-obese adults.
Does physical activity improve PI3K and Akt mRNA levels in adipose tissues of obese and non-obese adults?
Cross-Sectional (n=176)
Yes
Does physical activity improve PI3K and Akt mRNA levels in adipose tissues of obese and non-obese adults?
Physical activity is positively associated with increased PI3K and Akt mRNA expression in adipose tissue, suggesting a molecular mechanism for the metabolic benefits of exercise in obesity.
Supports hypothesis of exercise-linked adipose signaling in obesity; hypothesis-generating and should not yet change practice.
Phosphatidylinositol-3-kinase (PI3K)/Akt signaling pathway regulates glucose and lipid metabolism. We examined the association of PI3K and Akt expression in visceral (VAT) and subcutaneous adipose tissue (SAT) with daily physical activity (PA) in non-diabetic obese and non-obese adults. In this cross-sectional study, we included 105 obese (BMI ≥ 30 kg/m 2 ) and 71 non-obese (BMI < 30 kg/m 2 ) subjects (aged/ ≥ 18 years). PA was measured using a valid and reliable International Physical Activity Questionnaire(IPAQ)-long-form, and the metabolic equivalent of task(MET) was calculated. Real-time PCR was performed to analyze the mRNA relative expression. VAT PI3K expression had a lower level in obese compared to non-obese (P = 0.015), while its expression was higher in active individuals than inactive ones (P = 0.029). SAT PI3K expression was increased in active individuals compared to inactive ones (P = 0.031). There was a rise in VAT Akt expression in the actives compared to the inactive participants (P = 0.037) and in non-obese/active compared to non-obese/inactive individuals (P = 0.026). Obese individuals had a decreased expression level of SAT Akt compared to non-obsesses (P = 0.005). VAT PI3K was directly and significantly associated with PA in obsesses (β = 1.457, P = 0.015). Positive association between PI3K and PA suggests beneficial effects of PA for obese individuals that can be partly described by PI3K/Akt pathway acceleration in adipose tissue.
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Montazeri et al. (2023) conducted a cross-sectional in Obesity (n=176). Physical activity vs. Physical inactivity was evaluated on Association of physical activity with PI3K mRNA expression in visceral adipose tissue (VAT) of obese individuals (β = 1.46, 95% CI 0.29-2.62, p=0.015). Physical activity was directly and significantly associated with increased PI3K mRNA expression in the visceral adipose tissue of obese adults.
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