Key result
Flecainide exhibits a triple mode of action in CPVT by inhibiting INa, directly blocking RyR2 channels, and reducing the probability of DAD-triggered action potentials.
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Flecainide has a complex mechanism of action in CPVT, including direct inhibition of RyR2 gating and reduction of Ca2+ spark mass, which prevents pro-arrhythmic Ca2+ waves.
Steele et al. (2013) conducted a letter in Catecholaminergic polymorphic ventricular tachycardia (CPVT). Flecainide was evaluated. Flecainide exhibits a triple mode of action in CPVT by inhibiting INa, directly blocking RyR2 channels, and reducing the probability of DAD-triggered action potentials.
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