Population
324 Centre d' Etude du Polymorphisme Humain lymphoblastoid cell lines (24 pedigrees)
Design
Preclinical
Follow-up
72 h
Authors
Loading...
Genetic loci for daunorubicin cytotoxicity require human validation; leaves open any role in cardiotoxicity risk stratification.
Genetic determinants, including genes in the phosphatidylinositol signaling system, significantly contribute to susceptibility to daunorubicin-induced cytotoxicity in vitro.
Duan et al. (2007) studied this question.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: