Why the study?
Does IK1 blockade with BaCl2 terminate ventricular fibrillation in a guinea pig heart model?
Population
Guinea pig heart model (21 left ventricular and 20 right ventricular myocytes; 23 Langendorff-perfused hearts)
Comparison
Superfusion with BaCl2 to block IK1 vs Baseline control (0 micromol/L Ba2+)
Design
Preclinical
Authors
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IK1 blockade terminates VF in guinea pig hearts; leaves open whether this extends to human arrhythmia therapy.
Does IK1 blockade with BaCl2 terminate ventricular fibrillation in a guinea pig heart model?
Blockade of the inward rectifying potassium current (IK1) with barium terminates ventricular fibrillation in a guinea pig model, highlighting the role of IK1 in rotor stabilization.
Warren et al. (2003) studied this question.
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