January 1, 1994Journal of Cardiovascular Pharmacology
Barium Decreases Defibrillation Energy Requirements
Key result
Barium infusion cuts defibrillation energy requirements by ~60% at 120 minutes in preclinical testing.
- P<0.001
- n=17
Why the study?
The effect of blocking specific myocardial repolarizing currents, particularly inwardly rectifying potassium current (Ik1), on defibrillation energy requirements is not well understood.
Does barium decrease defibrillation energy requirements in an open-chest dog model?
Comparison
Barium infusion vs saline infusion
Design
Preclinical experimental study
Follow-up
120 minutes
Authors
Discussion
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Implication
Hypothesis-generating for IK1 inhibition to lower defibrillation thresholds; should not yet influence clinical practice.
Structured PICO
Does barium decrease defibrillation energy requirements in an open-chest dog model?
P
Population
17 dogs in an open-chest model assessing defibrillation energy and voltage requirements.
I
Intervention
Barium infusion (1.1 mg/kg/min for 5 min followed by 0.25 mg/kg/min) for 120 minutes
C
Comparator
Saline infusion (control)
O
Outcome
Energy and voltage for 50% success in defibrillation (E50 and V50)surrogate
Main Result
p-value: p=< 0.001
Inhibition of the inwardly rectifying potassium current with barium markedly decreases defibrillation voltage and energy requirements in a canine model.
Cite This Study
Dorian et al. (1994) studied Defibrillation (n=17). Barium vs. Saline was evaluated on Energy for 50% success in defibrillation (E50) at 120 min (p=< 0.001). Barium infusion significantly decreased the energy requirements for 50% success in defibrillation by 59.9% at 120 minutes in an open-chest dog model (p<0.001).