Key result
Terikalant and barium reduce VF induction vulnerability by up to ~34% versus vehicle in dogs.
Why the study?
Does terikalant or barium decrease the area of vulnerability to ventricular fibrillation induction in dogs?
Population
Dogs (n=30 total: 8 terikalant, 8 barium, 14 vehicle)
Comparison
Terikalant or barium vs Vehicle
Design
Preclinical
Authors
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Hypothesis-generating for class III antiarrhythmic effects on VF vulnerability; leaves open human translation and clinical testing.
Does terikalant or barium decrease the area of vulnerability to ventricular fibrillation induction in dogs?
Effect estimate: 34% and 28% decrease
p-value: p=<0.01
Potassium channel blockers terikalant and barium reduce the area of vulnerability to ventricular fibrillation induction, providing insight into the anti-fibrillatory action of class III anti-arrhythmic drugs.
Qi et al. (2002) studied Ventricular fibrillation vulnerability (n=30). Terikalant and Barium vs. Vehicle was evaluated on Area of vulnerability (AOV) to ventricular fibrillation induction (34% and 28% decrease, p=<0.01). Terikalant and barium decreased the area of vulnerability to ventricular fibrillation induction by 34% and 28% (p<0.01), respectively, compared to vehicle in dogs.
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