Key result
Due to the lack of official data on the therapeutic equivalence and interchangeability of generic forms of amlodipine, the original drug Norvasc should be preferred for the treatment of hypertension.
This review highlights the importance of pharmaceutical quality and therapeutic equivalence, suggesting a preference for original amlodipine over generics in the absence of proven interchangeability.
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May warrant preferring Norvasc for hypertension; leaves open generic amlodipine equivalence pending official data.
Selection of amlodipine (tablets) as a drug based on three basic criteria: clinical efficacy, safety / tolerability and quality is discussed below. The article deals with the successive stages of clinical pharmacology and pharmacotherapy from amlodipine tablets (pharmaceutical stage) to clinical response (therapeutic step). An algorithm for evaluating the interchangeability of reference and reproduced preparations containing Amlodipine is presented.
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А. С. Духанин (2016) conducted a review in Hypertension. Amlodipine (original vs generic) was evaluated. Due to the lack of official data on the therapeutic equivalence and interchangeability of generic forms of amlodipine, the original drug Norvasc should be preferred for the treatment of hypertension.
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