Why the study?
Are minimally invasive video-assisted techniques for skeletal muscle cardiac assistance feasible and safe in an animal model?
Are minimally invasive video-assisted techniques for skeletal muscle cardiac assistance feasible and safe in an animal model?
Minimally invasive video-assisted techniques for latissimus dorsi muscle harvest and cardiac wrapping are technically feasible in an animal model, potentially reducing surgical morbidity for skeletal muscle cardiac assistance.
Feasible in animal model; hypothesis-generating for human skeletal muscle cardiac assistance and requires clinical trials.
Skeletal muscle cardiac assistance as a treatment modality for heart failure is considered a high-risk procedure subject to strict patient selection. The aim here is to develop minimally invasive techniques to improve surgical outcomes and increase clinical indications. Ten yoats (45–55 kg) were studied. In six, the latissimus dorsi muscle (LDM) was harvested via an open technique on one side vs a minimally invasive technique on the other using video assistance through two 3 cm incisions. Surgical maneuvers and length of procedures were noted. Animals were recovered, observed daily for local complications, and killed after 1 week for comparative anatomic and histopathologic studies. In four other goats, minimally invasive aortomyoplasty or cardiomyoplasty was performed using video assistance (2 aortomyoplasty, 2 cardiomyoplasty). In this experimental series, there were no surgical complications. The minimally invasive LDM harvest required a mean of 81 min (range 55–116 mn) with no gross evidence of muscle damage. The technique of LDM harvesting was standardized and is reproducible. Aortic and cardiac wrapping were also achieved through three ports and a left minith-oracotomy of 4 cm, using the right or left LDM. A scarf technique for the descending aortomyoplasty using the left LDM, and an anterior wrapping for cardiomyoplasty using the left or right LDM was technically feasible with video assistance. This study suggests future clinical applicability. ASAIO Journal 1997;43:M791-M796.
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Mesana et al. (1997) studied this question.