What question did this study set out to answer?

To determine how age, biological sex, and combined oral contraceptive use influence the capacity of endothelial cells and prostacyclin to inhibit platelet aggregation and activation.

September 1, 1978Scandinavian Journal of Haematology

The Influence of Age, Sex, and the Use of Oral Contraceptives on the Inhibitory Effects of Endothelial Cells and PGI2 (Prostacyclin) on Platelet Function

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Why the study?

Do age, sex, and oral contraceptive use influence the inhibitory effects of endothelial cells and PGI2 on platelet function in healthy subjects?

Population

60 healthy subjects divided into 5 groups: 10 young women, 10 young women using combined oral…

Comparison

In vitro incubation of platelet-rich plasma with… vs Comparison across different age, sex, and oral…

Design

Cross-sectional

Authors

ANArne NordøyUiT The Arctic University of Norway BSBirgit SvenssonUniversity Hospital of North Norway DHDonna HaycraftUniversity of Iowa

Discussion

Member takes

Implication

May heighten thrombotic risk in OC users and postmenopausal women; leaves open causal role in clinical events.

Key Points

To determine how age, biological sex, and combined oral contraceptive use influence the capacity of endothelial cells and prostacyclin to inhibit platelet aggregation and activation.
Evaluated platelet-rich plasma from 60 healthy participants across five cohorts: young women (n=10), women taking combined oral contraceptives (n=10), postmenopausal women (n=10), younger men (n=20), and older men (n=10).
Assessed spontaneous, ADP-induced, and collagen-induced platelet aggregation alongside platelet factor 3 activity and malondialdehyde production after incubation with human endothelial cells, prostacyclin, or aspirin.
Spontaneous platelet aggregation appeared frequently in oral contraceptive users, postmenopausal women, and older men, but was completely prevented by endothelial cells, aspirin, or prostacyclin.
Endothelial cells significantly inhibited ADP-induced aggregation and collagen-induced malondialdehyde production, though inhibitory efficacy was significantly reduced in oral contraceptive users and postmenopausal women.
Prostacyclin exerted less inhibitory effect on ADP-induced platelet aggregation across all female cohorts compared to both male cohorts.

Structured PICO

Do age, sex, and oral contraceptive use influence the inhibitory effects of endothelial cells and PGI2 on platelet function in healthy subjects?

Population

60 healthy subjects divided into 5 groups: 10 young women (19-33 yrs), 10 young women (21-31 yrs) using combined oral contraceptives, 10 postmenopausal women (45-66 yrs), 20 young men (24-48 yrs), and 10 older men (48-71 yrs).

Intervention

In vitro incubation of platelet-rich plasma with human endothelial cells (ECM), aspirin (ASA), or PGI2 (prostacyclin)

Comparator

Comparison across different age, sex, and oral contraceptive use groups

Outcome

Inhibitory effects on platelet function (spontaneous, ADP-induced, and collagen-induced platelet aggregation, prostaglandin production, and platelet factor 3 activity)surrogate

Age, sex, and oral contraceptive use significantly alter the sensitivity of platelets to the inhibitory effects of endothelial cells and prostacyclin, which may contribute to differences in thrombotic risk.

Cite This Study

Nordøy et al. (1978) studied this question.

synapsesocial.com/papers/6a74a4ea84fffe492cdbd693 https://doi.org/10.1111/j.1600-0609.1978.tb00352.x

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The Influence of Age, Sex, and the Use of Oral Contraceptives on the Inhibitory Effects of Endothelial Cells and PGI2 (Prostacyclin) on Platelet Function

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

The Influence of Age, Sex, and the Use of Oral Contraceptives on the Inhibitory Effects of Endothelial Cells and PGI2 (Prostacyclin) on Platelet Function

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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