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Scientific commentary evaluates the biological relevance of ascorbic acid's pro-oxidant activity in vivo, suggesting insufficient evidence that it causes tissue damage.
Ascorbic acid has a multiplicity of antioxidant properties, but it can exert pro-oxidant effects in vitro, usually by interaction with transition metal ions. It is as yet uncertain that these pro-oxidant effects have any biological relevance: some of the available data are summarized.
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Barry Halliwell (1996) studied this question.
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