Two regions within the human IL-2 gene promoter are important for inducible IL-2 expression.

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Population

Jurkat T lymphoid line

Comparison

Transfection with human IL-2 gene promoter… vs Wild-type IL-2 promoter constructs

Design

Preclinical

Authors

Discussion

These promoter regions require human validation; leaves open their role in T-cell therapies for cardiovascular inflammation.

Population

Jurkat T lymphoid line

Intervention

Transfection with human IL-2 gene promoter constructs (5'-deletion and internal deletion mutants)

Comparator

Wild-type IL-2 promoter constructs

Outcome

Inducible chloramphenicol acetyl-transferase expression and cyclosporin A-mediated inhibitionsurrogate

Two discrete regions within the human IL-2 gene promoter (-42 to -169 and -289 to -361 bp) are critical for its inducible expression in T cells.

Williams et al. (1988) studied this question.

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