Key result
Men in the lowest quintile of FEV1 had a 3.5-fold increased risk for sudden cardiac death compared to those with higher lung function (95% CI 1.42-8.41; P=0.006).
Why the study?
Does impaired pulmonary function predict sudden cardiac death in middle-aged men?
Population
1250 men 42-60 years of age without chronic obstructive pulmonary disease, asthma, and lung cancer
Comparison
Impaired pulmonary function vs Normal or higher pulmonary function
Design
Cohort
Follow-up
20 years
Authors
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Low FEV1 may flag higher SCD risk in men; hypothesis-generating and should not yet change practice.
Cohort (n=1,250)
Does impaired pulmonary function predict sudden cardiac death in middle-aged men?
Relative Risk: 3.5 (95% CI 1.42–8.41)
p-value: p=0.006
Reduced lung function is a robust predictor of sudden cardiac death in middle-aged men, suggesting its potential utility in risk stratification.
Kurl et al. (2015) conducted a cohort in Sudden cardiac death risk in men (n=1,250). Reduced pulmonary function (lowest quintile of FEV1) vs. Higher pulmonary function was evaluated on Sudden cardiac death (SCD) (adjusted risk 3.5, 95% CI 1.42-8.41, p=0.006). Men in the lowest quintile of FEV1 had a 3.5-fold increased risk for sudden cardiac death compared to those with higher lung function (95% CI 1.42-8.41; P=0.006).