Transcriptional regulation of epithelial-mesenchymal transition
Authors
Discussion
Loading...
Member takes
Implication
Mechanistic study reveals a novel protein-DNA complex regulating FSP1 in transitioning cells, highlighting a core driver of the EMT transcriptome.
Key Points
- To elucidate the transcriptional mechanisms that coordinate cellular reprogramming during epithelial-mesenchymal transition.
- Analysis of fibroblasts derived through epithelial-mesenchymal transition.
- Characterization of transcription factor complexes regulating fibroblast-specific protein 1 (FSP1) gene expression.
- Identified a novel protein-DNA complex that is required for the transcription of fibroblast-specific protein 1 (FSP1).
- Demonstrated that assembly of this regulatory complex is sufficient to trigger early cellular hallmarks of epithelial-mesenchymal transition.
Cite This Study
Teng et al. (2007) studied this question.