Femoral venipuncture provides an effective and less stressful method for single or serial blood collection in nonanesthetized rats.
May improve welfare and data quality in rodent CV models; leaves open validation before wider adoption.
A technique for blood collection via the femoral vein was developed for use in nonanesthetized rats. The technique was useful for single or serial blood collection. Volumes of 0.1 to 1 ml were collected for serum biochemical or venous blood gas determinations. The technique was effective, reproducible, did not require anesthesia, and was less stressful than other methods of blood collection in the rat.
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Horton et al. (1986) studied this question.
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