Why the study?
Does captopril improve heart failure in a patient with phaeochromocytoma and catecholamine-induced cardiomyopathy?
Does captopril improve heart failure in a patient with phaeochromocytoma and catecholamine-induced cardiomyopathy?
Captopril, alone and in combination with phenoxybenzamine, rapidly reversed severe left ventricular heart failure in a patient with catecholamine-induced cardiomyopathy due to phaeochromocytoma.
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Suggests captopril may rapidly reverse catecholamine cardiomyopathy; hypothesis-generating, requiring confirmation beyond this single case.
A patient with a phaeochromocytoma and severe left ventricular heart failure caused by a catecholamine-induced cardiomyopathy is described. The clinical signs of congestive heart failure resolved rapidly on treatment with captopril and myocardial performance became normal within two weeks of medical treatment with captopril for one week and with captopril in combination with phenoxybenzamine for another week.
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Salathé et al. (1992) studied this question.
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