What question did this study set out to answer?

To review evidence detailing the normal presynaptic function of alpha-synuclein and analyze how its pathological aggregation leads to synaptic dysfunction.

September 1, 2013CNS & Neurological Disorders - Drug Targets

Synaptic Dysfunction in Synucleinopathies

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To review evidence detailing the normal presynaptic function of alpha-synuclein and analyze how its pathological aggregation leads to synaptic dysfunction.
Synthesized findings from published literature evaluating synaptic pathology in postmortem brains with alpha-synucleinopathies.
Reviewed mechanistic and phenotypic data from corresponding animal models of synuclein-mediated neurodegeneration.
Alpha-synuclein physiologically facilitates presynaptic neuronal signaling and neurotransmitter vesicle dynamics under normal conditions.
Pathological aggregation of alpha-synuclein into Lewy bodies and neurites markedly impairs neurotransmitter release mechanisms at the neuronal synapse.

Authors

OAOleg AnichtchikLeeds Teaching Hospitals NHS Trust LCLeonardo CalòElectrophysiology SMSpillantini MG

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Implication

Narrative review reveals synaptic disruption and impaired neurotransmitter release in synucleinopathies, highlighting presynaptic mechanisms behind neurodegeneration.

Cite This Study

Anichtchik et al. (2013) studied this question.

synapsesocial.com/papers/6a74b50a6a5eb4b8f509217c https://doi.org/10.2174/18715273113129990114

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Implication

Narrative review reveals synaptic disruption and impaired neurotransmitter release in synucleinopathies, highlighting presynaptic mechanisms behind neurodegeneration.

Synaptic Dysfunction in Synucleinopathies

Key Points

Discussion

Implication

Cite This Study

Synaptic Dysfunction in Synucleinopathies

Key Points

Discussion

Implication

Cite This Study