Key result
Mammalian-derived surgical materials trigger intraoperative anaphylactic collapse in undiagnosed alpha-gal syndrome.
Case Report (n=1)
No
Undiagnosed alpha-gal syndrome can cause life-threatening intraoperative anaphylaxis due to the use of mammalian-derived medications and surgical materials, necessitating awareness and potential preprocedural screening in endemic areas.
Answers are grounded in this paper and cite their sources.
May warrant alpha-gal evaluation in unexplained intraoperative anaphylaxis; leaves open need for targeted screening in endemic areas.
BACKGROUND: Alpha-gal syndrome (AGS) is a delayed allergic reaction to galactose-α-1,3-galactose, a carbohydrate in nonprimate mammalian tissue. Reactions can occur in individuals exposed to lone star ticks after consuming red meat and dairy products and/or exposure to mammal-derived medications or bioprosthetic materials. CASE SUMMARY: A 74-year-old man undergoing valve and ascending aortic replacement experienced hemodynamic collapse after transfusion of heparin, fresh frozen plasma, and platelets. Transfusion reaction, cardiogenic shock, and sepsis were ruled out. Recovery occurred within 6 hours of medical treatment. After an otherwise uncomplicated hospitalization, he was diagnosed with AGS and treated with diet restriction and omalizumab. DISCUSSION AND TAKE-HOME MESSAGES: In addition to anaphylaxis, AGS may also have long-term cardiovascular effects such as early bioprosthetic valve failure, accelerated atherosclerosis, and coronary artery disease. Understanding of clinical subtleties of AGS and its cardiovascular implications is important for clinicians who manage these patients both in the short and long terms.
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Henderson et al. (2025) conducted a case report in Alpha-Gal Syndrome, Aortic Stenosis, Ascending Aortic Aneurysm (n=1). Mammalian-derived surgical materials and medications (heparin, bioprosthetic valve, gelatin-coated graft) was evaluated. Exposure to mammalian-derived medications and surgical materials in a patient with undiagnosed alpha-gal syndrome resulted in intraoperative anaphylactic shock and hemodynamic collapse.
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