An in vitro method was developed to determine the rate of drug release from a liposome formulation. Liposome formulation containing metaproterenol sulfate was evaluated for release of the drug over a 24-hour period in an end-over-end tumbler device. Drug release appeared to be a function of all the operating parameters, such as rotational speed of the end-over-end tumbler, temperature of suspension, and the geometry of sample container that is placed in the end-over-end tumbler device.
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Vemuri et al. (1991) studied this question.
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