Key result
P2X2-1 was the most common transcript in guinea pig myenteric neurons (92%) and displayed slower desensitization and higher sensitivity to ATP, BzATP, PPADS, and Zn2+ compared to P2X2-2.
Population
Guinea pig myenteric neurons and Xenopus laevis oocytes used for expression of P2X2 variants.
Comparison
Cloning and expression of P2X2 splice variants… vs Comparison between different P2X2 splice variants.
Design
Preclinical
Authors
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Animal findings on P2X2-1 should not guide human therapies; leaves open splice variant roles in enteric ATP signaling.
Retention of intron 11 in the P2X2-1 variant is the most common transcript in guinea pig myenteric neurons and significantly alters the receptor's pharmacological and kinetic properties in ATP signaling.
Liñán-Rico et al. (2012) studied this question. P2X2 splice variants (P2X2-1, P2X2-2, P2X2-4) was evaluated on Pharmacological and kinetic properties of P2X2 splice variants. P2X2-1 was the most common transcript in guinea pig myenteric neurons (92%) and displayed slower desensitization and higher sensitivity to ATP, BzATP, PPADS, and Zn2+ compared to P2X2-2.
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