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January 1, 2000The Japanese Journal of PharmacologyOpen Access

Antiplatelet and Antithrombotic Effects of a Novel Selective Phosphodiesterase 3 Inhibitor, NSP-513, in Mice and Rats

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Population

Human platelets (in vitro), mouse pulmonary thromboembolism model, and rat carotid arterial thrombosis model

Comparison

NSP-513 vs Cilostazol, aspirin, and dipyridamole

Design

Preclinical

Authors

HHHiroyasu HiroseFood Research InstituteTKToshifumi KimuraFujifilm (Japan)MOMegumu OkadaUniversity of Tsukuba

Discussion

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Implication

Hypothesis-generating for selective PDE3 inhibition in thrombosis; requires human trials before any clinical consideration.

Structured PICO

P
Population
Human platelets (in vitro), mouse pulmonary thromboembolism model, and rat carotid arterial thrombosis model
I
Intervention
NSP-513 (in vitro, oral in mice, intraduodenal 0.1 mg/kg in rats)
C
Comparator
Cilostazol (oral in mice, intraduodenal 30 mg/kg in rats), aspirin (intraduodenal 30 mg/kg in rats), and dipyridamole (intravenous 10 mg/kg in rats)
O
Outcome
Phosphodiesterase (PDE) isozyme activities, in vitro platelet aggregation, and in vivo thrombus formationsurrogate

NSP-513 is a highly selective PDE3 inhibitor with potent in vitro antiplatelet and in vivo antithrombotic effects in rodent models.

Cite This Study

Hirose et al. (2000) studied this question.

synapsesocial.com/papers/6a74bb15508d802509f54706https://doi.org/10.1254/jjp.82.188
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Also Consider

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  3. 3Pharmacology of platelet inhibition in humans: implications of the salicylate-aspirin interaction.1985 · 103 citations
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