Key result
Adaptive servoventilation significantly reduced muscle sympathetic nerve activity and stabilized respiration compared to continuous positive airway pressure in patients with heart failure and periodic breathing.
Why the study?
Does adaptive servoventilation reduce muscle sympathetic nerve activity compared to continuous positive airway pressure in patients with heart failure?
RCT (n=57)
Single-blind (outcomes assessor)
Randomized
No
Does adaptive servoventilation reduce muscle sympathetic nerve activity compared to continuous positive airway pressure in patients with heart failure?
Absolute Event Rate: 38% vs 40%
p-value: p=0.003
Short-term adaptive servoventilation, but not continuous positive airway pressure, effectively reduces muscle sympathetic nerve activity and stabilizes respiration in heart failure patients with periodic breathing.
Favors adaptive servoventilation over CPAP for acute sympathetic suppression in HF with periodic breathing; extends physiological data via RCT.
BACKGROUND: Long-term adaptive servoventilation (ASV) increases cardiac function more effectively than continuous positive airway pressure (CPAP), possibly via alleviation of sympathetic overactivation. The present study evaluated the effect of ASV and CPAP at comparable pressure on muscle sympathetic nerve activity (MSNA) in patients with heart failure (HF) and with or without periodic breathing (PB). METHODS AND RESULTS: A total of 57 patients with HF (ejection fraction <0.45) were randomized to receive CPAP (n=28) or ASV (n=29). Respiratory profiles and MSNA were continuously monitored before and during CPAP and ASV (30min) at pressures of 6.5 and 6.6cmH2O, respectively. The severity of respiratory instability was determined using the coefficient of variation of tidal volume (CV-TV). Although heart rate and blood pressure remained unchanged, only ASV improved CV-TV. MSNA decreased in the ASV (P<0.001), but not in the CPAP group. The change in CV-TV independently predicted changes in MSNA (P<0.001). Device type and PB significantly interacted with changes in MSNA (P<0.05) and ASV exerted sympathoinhibitory effects in patients with PB, whereas CPAP did not. A sympathoinhibitory effect in patients without PB was not evident in either treatment arm. CONCLUSIONS: ASV probably exerts its sympathoinhibitory effects in patients with HF and PB through pressure support.
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Ushijima et al. (2014) conducted an RCT in Heart failure (n=57). Adaptive servoventilation vs. Continuous positive airway pressure (CPAP) was evaluated on Muscle sympathetic nerve activity (burst rate, bursts/min) (p=0.003). Adaptive servoventilation significantly reduced muscle sympathetic nerve activity and stabilized respiration compared to continuous positive airway pressure in patients with heart failure and periodic breathing.
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