Impact of Subclinical Atherosclerosis on Cardiovascular Disease Events in Individuals With Metabolic Syndrome and Diabetes
Key result
Coronary artery calcium scores >0 strongly predicted coronary heart disease in individuals with metabolic syndrome (HR 3.9-11.9) and diabetes (HR 2.9-6.2) compared to a score of 0.
Why the study?
Does screening for CAC and CIMT improve CVD risk stratification over traditional risk factors in people with metabolic syndrome and diabetes?
Population
6,603 people aged 45-84 years in the Multi-Ethnic Study of Atherosclerosis, including 1,686 with metabolic…
Comparison
Screening for coronary artery calcium and… vs Traditional risk factors (RFs)
Design
Cohort
Follow-up
6.4 years
Authors
Discussion
Loading...
Member takes
Implication
CAC may enhance CHD risk stratification in metabolic syndrome and diabetes; hypothesis-generating and should not yet change practice.
Study Design
Type
Cohort (n=6,603)
Structured PICO
Does screening for CAC and CIMT improve CVD risk stratification over traditional risk factors in people with metabolic syndrome and diabetes?
P
Population
6,603 individuals aged 45-84 years, including 1,686 with metabolic syndrome and 881 with diabetes, followed for 6.4 years.
E
Exposure
Screening for coronary artery calcium (CAC) and carotid intimal-medial thickness (CIMT)
C
Comparator
Traditional risk factors (RFs)
O
Outcome
Coronary heart disease (CHD) and cardiovascular disease (CVD) events over 6.4 yearshard clinical
Main Result
Effect estimate: HR 2.9 to 11.9
p-value: p=<0.05 to <0.001
Screening for coronary artery calcium significantly improves cardiovascular risk prediction beyond traditional risk factors in individuals with metabolic syndrome or diabetes.
Cite This Study
Malik et al. (2011) conducted a cohort in Metabolic syndrome and diabetes (n=6,603). Coronary artery calcium (CAC) and carotid intimal-medial thickness (CIMT) vs. CAC 0 was evaluated on Coronary heart disease (CHD) and cardiovascular disease (CVD) (HR 2.9 to 11.9, p=<0.05 to <0.001). Coronary artery calcium scores >0 strongly predicted coronary heart disease in individuals with metabolic syndrome (HR 3.9-11.9) and diabetes (HR 2.9-6.2) compared to a score of 0.