Why the study?
Does modulation of sympathetic innervation with nerve growth factor or its antiserum affect ventricular impulse propagation and repolarisation in neonatal rats?
Population
Neonatal rats
Comparison
Nerve growth factor or its antiserum… vs Placebo
Design
Preclinical
Follow-up
10 days
Authors
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Sympathetic innervation may modulate neonatal ventricular conduction and repolarization; hypothesis-generating for mechanisms of human QT prolongation.
Does modulation of sympathetic innervation with nerve growth factor or its antiserum affect ventricular impulse propagation and repolarisation in neonatal rats?
Retardation of sympathetic innervation in neonatal rats slows conduction velocity and prolongs epicardial action potential duration, providing a mechanistic explanation for prolonged QT intervals.
Sun et al. (1993) studied this question.
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