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August 1, 1988Annals of the New York Academy of Sciences

Sympathetic Neural and α‐Adrenergic Modulation of Arrhythmiasa

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Why the study?

Does sympathetic innervation modulate the alpha-adrenergic response on ventricular automaticity in neonatal and adult heart tissues?

Population

Isolated tissues from the hearts of neonatal and adult dogs and rats, and rat myocytes in tissue culture…

Comparison

alpha 1-Adrenergic stimulation and… vs Uninnervated myocytes vs innervated myocytes

Design

Preclinical

Authors

MRMichael R. RosenPDPeter DaniloRRRichard B. Robinson

Discussion

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Overview

Hypothesis-generating for sympathetic modulation of ventricular automaticity; leaves open human arrhythmogenic relevance.

Structured PICO

Does sympathetic innervation modulate the alpha-adrenergic response on ventricular automaticity in neonatal and adult heart tissues?

P
Population
Isolated tissues from the hearts of neonatal and adult dogs and rats, and rat myocytes in tissue culture alone or in coculture with sympathetic nerves
I
Intervention
alpha 1-Adrenergic stimulation and ADP-ribosylation with pertussis toxin
C
Comparator
Uninnervated myocytes vs innervated myocytes
O
Outcome
Ventricular automaticitysurrogate

Sympathetic innervation modulates cardiac rhythm via a GTP regulatory protein, suggesting that abnormal neuronal development may predispose to arrhythmogenesis.

Cite This Study

Rosen et al. (1988) studied this question.

synapsesocial.com/papers/6a214c69bd959c3a83ab97cahttps://doi.org/10.1111/j.1749-6632.1988.tb37249.x
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