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September 1, 1985Circulation ResearchOpen Access

Phenylephrine increased automatic rate in neonatal rat ventricle (115 to 168 beats/min, p<0.05) and non-innervated cultures (40 to 52 beats/min, p<0.05), but decreased rate in adult rat ventricle (36 to 12 beats/min, p<0.05) and innervated cultures (78 to 67 beats/min, p<0.05).

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Population

Neonatal and adult rat ventricle, and cultures of neonatal rat myocytes

Comparison

Phenylephrine (1 X 10 M) with or without… vs Baseline automatic rate; non-innervated vs…

Design

Preclinical

Authors

EDElizabeth DruggeMRMichael R. RosenRRRichard B. Robinson

Discussion

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Overview

Alpha-adrenergic chronotropic responses vary by age and innervation in rat models; leaves open translation to human electrophysiology.

Structured PICO

P
Population
Neonatal and adult rat ventricle, and cultures of neonatal rat myocytes (innervated with sympathetic neurons and non-innervated)
I
Intervention
Phenylephrine (1 X 10(-8) M) with or without prazosin (1 X 10(-6) M)
C
Comparator
Baseline automatic rate; non-innervated vs innervated cultures
O
Outcome
Automatic rate (beats/min) in response to alpha-adrenergic stimulationsurrogate

Sympathetic innervation modulates the myocardial response to alpha-adrenergic stimulation, explaining the developmental shift from a positive to negative chronotropic effect.

Cite This Study

Drugge et al. (1985) studied this question.

synapsesocial.com/papers/6a882102e0903042354def14https://doi.org/10.1161/01.res.57.3.415
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