Alpha1-adrenergic-induced hypertrophy in neonatal rat ventricular myocytes leads to significant electrophysiological remodeling, including prolonged action potential duration and reduced L-type Ca2+ and transient outward K+ currents.
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Should not change practice; leaves open whether α1-adrenergic remodeling drives human arrhythmia risk.
Gaughan et al. (1998) studied this question.
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