Population
Primary culture of ventricular cardiomyocytes from newborn rats
Comparison
Norepinephrine 2 microM, with or without… vs Control conditions
Design
Preclinical
Follow-up
6 days
Authors
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Suggests alpha-adrenergic hypertrophy signaling in neonatal rat cells; hypothesis-generating and leaves open human relevance.
Norepinephrine stimulates hypertrophic growth and increases L-type calcium current density in neonatal rat cardiomyocytes via alpha-adrenergic receptor activation.
Pignier et al. (1998) studied this question.
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