Population
Cultured parasympathetic neurons from rat intracardiac ganglia
Comparison
Norepinephrine and other alpha-adrenergic agonists vs Absence of norepinephrine (baseline conditions)
Design
Preclinical
Authors
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NE may modulate vagal control via ICa inhibition in cardiac neurons; leaves open translation to human autonomic regulation.
Norepinephrine inhibits calcium currents in rat parasympathetic cardiac neurons via an atypical alpha-adrenergic receptor.
Xu et al. (1993) studied this question.
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