Key result
shRNA-mediated knockdown of HuR in the myocardium significantly reversed MI-induced left ventricular dysfunction, remodeling, apoptosis, infarct size, and fibrosis in IL-10-null mice.
Why the study?
Does shRNA-mediated knockdown of HuR attenuate post-MI inflammatory response and left ventricular dysfunction in IL-10-null mice?
Does shRNA-mediated knockdown of HuR attenuate post-MI inflammatory response and left ventricular dysfunction in IL-10-null mice?
HuR knockdown mimics the anti-inflammatory effects of IL-10, attenuating post-MI left ventricular dysfunction and adverse remodeling in a preclinical model.
No takes yet. Share an insight, caveat, or question.
HuR knockdown merits exploration as a post-MI target in IL-10 deficiency; leaves open clinical translation.
Krishnamurthy et al. (2010) studied Myocardial infarction. shRNA-mediated knockdown of HuR was evaluated on Left ventricular dysfunction and remodeling. shRNA-mediated knockdown of HuR in the myocardium significantly reversed MI-induced left ventricular dysfunction, remodeling, apoptosis, infarct size, and fibrosis in IL-10-null mice.
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