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August 1, 2004Thyroid

Evaluation of Endothelial Function in Subclinical Hypothyroidism and Subclinical Hyperthyroidism

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Why the study?

Does subclinical hypothyroidism or hyperthyroidism impair endothelial function or increase carotid IMT compared to euthyroid subjects?

Population

61 subjects, comprising 25 with subclinical hypothyroidism, 13 with subclinical hyperthyroidism, and 23…

Comparison

Subclinical hypothyroidism and subclinical… vs Euthyroid subjects

Design

Cross-sectional

Authors

AÇAyşe Sertkaya ÇıkımInonu UniversityHOHüseyin OflazInterventional CardiologyNÖNeşe ÖzbeyIstanbul University

Discussion

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Implication

Subclinical hypothyroidism may signal early endothelial impairment; hypothesis-generating and requires longitudinal studies before clinical adoption.

Structured PICO

Does subclinical hypothyroidism or hyperthyroidism impair endothelial function or increase carotid IMT compared to euthyroid subjects?

P
Population
61 subjects, comprising 25 with subclinical hypothyroidism (mean age 32.28), 13 with subclinical hyperthyroidism (mean age 35.69), and 23 euthyroid subjects (mean age 35.87), matched for atherosclerotic risk factors.
I
Intervention
Subclinical hypothyroidism and subclinical hyperthyroidism (exposures)
C
Comparator
Euthyroid subjects
O
Outcome
Endothelial function measured by flow-mediated dilatation (FMD) and carotid artery intimae-media thickness (IMT)surrogate

Subclinical hypothyroidism is associated with impaired endothelial function independent of traditional atherosclerotic risk factors.

Cite This Study

Çıkım et al. (2004) studied this question.

synapsesocial.com/papers/6a74c3f60081fe7b05dbe90chttps://doi.org/10.1089/1050725041692891
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Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Flow-Mediated, Endothelium-Dependent Vasodilatation Is Impaired in Subjects with Hypothyroidism, Borderline Hypothyroidism, and High-Normal Serum Thyrotropin (TSH) Values1997 · 237 citations
  2. 2Expression of vascular adhesion molecules on human endothelia in autoimmune thyroid disorders1995 · 37 citations
  3. 3The thyroid and the heart.1993 · 469 citations